Three Yale professors will use a $15 million grant from the National Institute on Drug Abuse (NIDA) to study single-cell opioid responses and other substance use disorder projects.
According to the Yale School of Medicine, NIDA awarded the five-year grant to Drs. Serena Spudich, a professor of neurology; Mark Gerstein, a professor of molecular biophysics and biochemistry; and Yuval Kluger, a professor in pathology.
Started on Aug. 1, the grant will establish a data center to coordinate, analyze and make accessible single-cell and other data sets generated by single-cell opioid responses in the context of HIV and other HIV and substance use disorder projects.
Both opioid use disorder and HIV infections can impact behavior and cognitive ability – either in combination or independently. But little is known on how the brain cells and brain’s circuits are altered in association with these two conditions. Additionally, HIV can stay in the brain for the long-term. The research done by the Yale group would look at which cells and which areas of the brain are involved in OUD and HIV, separately and together, to improve understanding of the effects OUD and HIV have on the brain.